Z-YVAD-FMK: Redefining Caspase-1 Inhibition for Translati...

2025-10-21

This thought-leadership article explores the mechanistic foundations and translational impact of caspase-1 inhibition using Z-YVAD-FMK. Integrating recent findings on the HOXC8-caspase-1 axis in lung cancer, it offers strategic guidance for researchers investigating apoptosis, inflammasome activation, and pyroptosis in cancer and neurodegenerative models. The article compares Z-YVAD-FMK to alternative inhibitors, highlights best practices in experimental design, and charts new directions for leveraging caspase-1 modulation in disease modeling and therapeutic innovation.